(362) Testosterone Replacement Therapy for Management of Cachexia: A Review of Current Literature

Abstract Introduction Cachexia is a progressively debilitating loss of skeletal muscle often seen in late-stage chronic medical diseases, such as cancer, HIV/AIDS, obstructive pulmonary disease (COPD), and liver cirrhosis. contributes to mortality morbidity with reduced quality-of-life (QoL) treatment options, can be associated adult-onset hypogonadism (AOH), which commonly treated testosterone replacement therapy (TRT) men. Objective This comprehensive review highlights the current literature on TRT for management patients disease-associated cachexia, an emphasis clinical outcomes side effects. Specifically, we identify highlight relevant primary reviews published since 2000 COPD, Methods A PubMed was performed articles between 2000-2021 cachexia-related diseases (cancer, cirrhosis) use AOH male cachexia. The list studies generated by initial search screened eligible studies. Inclusion criteria included outcome measures related changes lean body mass, composition, QoL, fatigue scores, and/or exercise addition meta-analyses. Results 12 were our out 653 results (Table 1). In three cancer patients, there mixed effects QoL assessment. Across COPD consistent improvement capacity condition TRT. four HIV-infected men, resulted notable weight, function, QoL. Lastly, two cirrhosis, improved strength composition across both cohorts. Conclusions Based recent studies, robust data benefits certain subgroups cachexic specifically those HIV, Because cachexia further investigation its long-term efficacy warranted, hormonal female patients. Disclosure No